ANTIDESTRUCTIVE ACTION OF GLUCOCORTICOIDS AT EARLY REUMATOID ARTHRITIS
ANTIDESTRUCTIVE ACTION OF GLUCOCORTICOIDS AT EARLY REUMATOID ARTHRITIS
Ahunova N.T., Holova Z.U., *Niyazov F.I.
ANTIDESTRUCTIVE ACTION OF GLUCOCORTICOIDS AT EARLY REUMATOID ARTHRITIS
Department of Therapy of the State Education Establishment “Institute of Postgraduate Education in Health Sphere of Republic of Tajikistan”
*Department of Internal Disease № 3 of the Tajik Medical State University named after Abuali-ibn-Sino
Aim. Study of antidestructiveactionsofglucocorticosteroids on the background of the basic treatment of early rheumatoid arthritis by methotrexate.
Materials and methods. Present results of treatment of 42 patients (all women) in the age of 32 to 58 years (mean 45 years). Duration of disease from 0,5 to 2 years with a valid RA (ARA criteria, 1987), observed during the year. Exclusion criteria were the presence of stomach ulcer or 12-duodenal ulcer. Patients with IV stage of radiographic disease. All patients were divided into two groups: 1 — 22 persons receiving methotrexate 10 mg per week and glucocorticosteroids7.5mg / day; 2 — 20 patients treated only by methotrexate. Nonsteroidal anti-inflammatory drugs were allowed in both groups. To assess the therapeutic effect was used clinical, laboratory and radiographic performances.
Results. In the 1st group in 8 of 22 patients decline was registered of the index of Larsen. Mainly due to the decrease or disappearance of cystoid enlightenment and of phenomena of periarthric osteoporosis. In the second group decrease of this indicator was observed only in three patients. Reduction of the index of Larsen did not correlate with the expected decrease in erosion, growth of erosions in the two groups was almost the same (2.0 and 2.4 respectively).
Conclusion. In patients with early rheumatoid arthritis reception of corticosteroids in combination with methotrexate helps to reduce osteochondral destruction, estimated by the index of Larsen.
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