Tuychiboeva M.N., Ahmedova A.A., Mu- hammadnazirzoda N., Muradov A.M.
Results of analysis of blood characteristics of the patients with sepsis and estimation of its toxic components markers are presented, and revealed that as one of markers adequately reflecting intoxication degree at an early stage of development of pathology levels of molecules of the average weights which research is obviously important and also perspective with the use of gel-chromatographic and Infrared- spectrometer methods can serve.

Sodiqov A. M., Murodov A. M., Hamroqulov A. A., Shumilova O. V.
The data obtained indicate excessively slow recovery of lost functions, which is most intense during the first 2 – 3 years and indicate the need for prolonged recovery of renal function for more than 6-7 years, deterioration of renal function contributed to: a chronic underlying disease (chronic glomerular – pyelonephritis, anemia, and subsequent pregnancy and childbirth in the background is not completely recovered renal function). Therefore, this group of patients should be on the dispensary to the full restoration of the functional usefulness of the kidneys, at least 2-3 years, and patients with chronic renal failure observed in different stages – for life

Aim. To develop and implement programs for the Epidemiological Monitoring of nosocomial infections in surgical departments, according to the recommendations of the Ministry of Health of the Republic of Tajikistan on the need to create model programs for each department, as well as some projects WHO.

Aim. Preventive maintenance prosthetic’s gingivitis in system of metalceramic designs with use of fermentcontaining toothpastes.

KASYMOV O.I., KASYMOV A.O.
THE DEPARTMENT OF DERMATOVENEROLOGY OF TIPGPMP
The article shows the efficiency of complex method of treatment of mycosis stop with onychomycosis in elderly and senile ages using immunostimulant thymocine 45 patients aged 60 to 85 years. Using methods of bacteriological research, 64.4% of the patients were grown culture of Trichophyton rubrum, in 11.1% of Trichophyton mentagrophytis var.interdigitale, in 24.4% – fungi not sown. Intertriginous form of mycosis stop diagnosed in 12 patients, dishydrotic – 6, mixed – 18. Combination squamous and intertriginous forms was observed in 11 patients, squamous, dishydrotic and intertriginous – for 7. The erased form of mycosis stop was noted in 9 patients. Immediate and remote results of treatment showed a significant advantage of an integrated method of treatment with the application of immune system stimulant. By the end of 6 months of follow-up highly effective results when immunostimulating therapy were achieved in 83,3% of patients in the group of patients treated without immunomodulator, efficiency indicator accounted for 61.9%. Among patients with total-dystrophic and proximal forms of combined treatment of onychomycosis gave clinical and mycological recovery in 66.7%, without immunostimulant – only 50%. The average speed of growth of nail plates stop in complex treatment using thymocine amounted to 1.37±0.06 mm per month, which is much faster than in the treatment only systemic antimycotics. The obtained results have shown the effectiveness of immunostimulating method of treatment of athlete’s foot with onychomycosis, compared with the traditional.

SHUMILINA O.V., MURADOV A.M.
DEPARTMENT OF EFFERENT MEDICINE AND INTENSIVE THERAPY OF STATE EDUCATIONAL ESTABLISHMENT «INSTITUTE OF POSTGRADUATE EDUCATION IN HEALTH SPHERE OF REPUBLIC OF TAJIKISTAN»
Indirect electrochemical oxidation is the process of modulating mono-oxygenized oxidation in liver on cytochrome R-450. Herewith the hydrophobic toxic components moves into hydrophilic which later on actively removes from organism by excreting organs. By using special electrochemical equipments, the isotonic saline solution exposes elec¬trolyses, transforms into hypo chloride sodium, that appear to be highly active oxidation with broad range impact. As for external and intra cavity use the medicine showed up as active antiseptic, necrolitic and anti-inflammatory agent. In intravascular injection of therapeutically concentration of the hypo chloride sodium (0,06%) renders remarkable detoxication effect. Promote hypo coagulation and improve the reologic characteristics of blood. Farther redistribu-tion intracellular and serum concentration of electrolytes , that effectively normalize metabolic disorders, provides also control of bacteria grow , decreases the resistant of microorganisms to antibiotics, cause indirect correction of immune system. Effectively decries the blood concentration of hydrophobic, hydrophilic, amfiphilic toxic compounds, corrects the hyperglycemia and hyperlipidemia. These all the characteristics of indirect oxidation has been widely im¬plemented in different field of medicine: surgery, efferent medicine, stomatology, obstetric and gynecology , oncology, dermatovenerology, infectious diseases etc.

MUKHAMADIEVA S.M.
DEPARTMENT OF OBSTETRICS AND GYNECOLOGY TIPGPMP
Many of the problems associated with a reduction in reproductive losses have not been ful¬filled. In the given aspect determining role belongs to the provision of contraceptive security. To understand the knowledge, attitudes and practices of women of reproductive age who use family planning services, those who are these services are provided, and also to determine the quality of contraceptive assistance to the population of medical institutions, conducted socio-logical research on the quality use of contraceptives by women of reproductive age. A specially designed questionnaire survey was conducted among 200 specialists of medical institutions for a professional assessment of knowledge, attitude and practice professionals providing contra¬ceptive services in the Republic. There was set low level of awareness of modern methods of contraception, the confidentiality of provision of contraceptive services and principles of coun-seling, post-Natal and postabortal contraception and voluntary surgical sterilization, methods of emergency contraception, indications and rules of their use, on the principles of counseling condom use. Specialists have an insufficient level of knowledge on the indication, duration of use and unwanted effects with the use of oral contraceptives and Depo-Provera.

BAKHROMI M.T.
THE DEPARTMENT OF CARDIOLOGY WITH THE COURSE OF CLINICAL PHARMACOLOGY TIPGPMP
The article presents results of studies on the action of a solution trionini on the cardiovas¬cular system. Work is based on the experiment on animals: 20 white rats weighing 200-220 g, cats weight from 3 to 4 kg under uretan anesthesia. Impact trionini on blood pressure were also studied in healthy intact rabbits and rabbits with experimental caused by atherosclerosis. There were 86 series of experiments conducted more than 150 biochemical, 25 haematological analy-ses, prepared 40 drugs from the internal organs of the experimental and control series animals. Heart rate became less 20-22%, the amplitude of the pulse wave increased respiratory activity remained unchanged. There has been little increase of pulse wave and slowing the pace of car¬diac function at 8-10%. In rabbits with atherosclerosis latent phase actions trionini reached 26 seconds, in healthy animals, it was 3-5 sec., that can be associated with morphological changes in the aorta, as well as changes in the General reactivity of the cardiovascular system. The results obtained allow to note that the developed solution trionini whose performance is not inferior to the well-known drugs.

KARIMOVS.M., MAKHMUDOVD.T., GUREZOVM.R., YORAKOVF.M.
Pathological changes of the periodontal tissue beside examined patient greatly connection with the general reaction of the organism, which is characterized it is enough high degree and reaction heart and vessels systems. Degree of the defeat periodontal fabric is determined level to accustomed motor activity and each functional type has their own physiological particularities of the factors heart and vessels systems and corresponding to reaction periodontal fabric on damaging factor of the system nature.

SIRODZHOV K.KH., RAHIMOV A.T.
THE DEPARTMENT OF TRAUMATOLOGY AND ORTHOPEDICS TIPGPMP
The unsatisfactory results of complex treatment of skeletal injuries and injury outcomes in patients polytrauma testify to the social and economic importance. The paper analyzes the results of studying the peculiarities of the structure of multiple and associated injuries skeleton, ways to optimize the treatment of fractures on the basis of orthopedic «Damage control» of 30 trauma patients. In the structure of combined trauma of the skeleton in the 81,7% of cases, there were fractures of long bones, 36,3% – fractures of other departments, 21,3% – pelvic bones, in 5,3% of cases – fracture of the spine. Fractures of the long bones in 78,4% of cases were of indoor and 21,6% of cases – the open character. Methods of early reposition fractures in the study group used in 30,4% of the observations, delayed – 15,7%, and later – in 9,5% of cases. In the control group received digital values amounted to, respectively, of 15,4%, 11,4 per cent to 17,3 per cent. Fractures of long bones of victims of the main group in 51,8% of the observations used for conservative treatment, 48,2% – by various methods of osteosynthesis with the use of stable forms (36,5%) and methods of osteosynthesis with additional external immobilization (11,7%).