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СЛОВО ГЛАВНОГО РЕДАКТОРА
Наше издание является научно-практическим журналом, в котором публикуются основные научные результаты диссертаций на соискание ученой степени кандидата и/или доктора медицинских наук как нашего института, так и других лечебно-учебных медицинских учреждений, интересные случаи из практики, обзоры литературы, лекции и юбилейные статьи. Журнал выходит 4 раза в год, и каждый номер имеет не менее 80 страниц. Каждая поступающая статья принимается по требованиям, проходит строгий отбор и отдается для выпуска в номер только после рецензирования и обязательного редактирования.
У нас принято одностороннее слепое рецензирование. Рецензенты уделяют особое внимание содержанию статьи и проверке данных статистической обработки, их соответствие современным требованиям.Главный редактор журнала доктор медицинских наук Мухиддинов Н. Д.
INFLUENCE OF MELDONY ON CARDIOTOXITY OF DOXORUBICINE IN PATIENTS WITH ACUTE LEUKEMIAS
RASULOV U.R., SHARIFOV M.M., SHAMSOV A.T., KHASANOV D.M., RAKHIMOV B.R., SUN’ATULLOEV D.S.
THE DEPARTMENT OF THE INTERNAL DISEASES №3 TSMU BY NAME ABUALI IBN SINA THE DEPARTMENT OF THERAPY WITH COURSE OF THE ENDOCRINOLOGY TIPGPMP
Acute leukemia, as a rare disease, is only 3% of human malignancies. The aim of treatment of acute leukemia is eradication of leukemic clone restore normal blood, achieveming long-term disease free survival of patients. This is achieved through the use of myelotoxical anticancer drugs that cause deep aplasia haemopoesis. In the present
paper summarises the results of the antitumor antibiotic antratcycline stimulants doxorubicin, with a joint appointment cardioprotector meldony. Under the supervision were 147 patients with acute leukemia. Among the observed patients 85 people received chemotherapy initially, 62 people – previously been subjected to chemotherapy effects. For the induction of remission patients of the 1st group was appointed polychemotherapy by the scheme “7+3”. Patients in group 2 received similar polychemotherapy together with cardioprotector Mildronate. During the treatment of patients of group 1 in 32% of cases were observed sinus tachycardia, atrial and ventricular arrhythmia, changes in segment ST, 7% of cases developed a complete atrioventricular block that shows the development of early cardiac toxicity of doxorubicin. In 19,04% of cases in patients of group 2 were observed ventricular tachycardia, and changes in segment ST.
ENDOPROTEZIROVANIE BONE DEFECT AT OSTEOMIELITIS OF THE MANDIBLE
MIRZOEV M.SH., SHAKIROV M.N., GAFAROV KH.O., SHAKIROV M.K.
The Organized analysis еndoprotezirovanie bone defect beside 14 sick with chronic osteomieli¬tis of the mandible different genesis. As endoprotesis are used different designs from porous-perme¬able nickelid of titanium, made as industrial, so and with provision for the individual parameter with using stereolitografiy technology.
Preventive maintenance and therapy of shortage of iron in an organism at pregnancy
Nurmatova Z.I., Nurmatov A.A., N.I. Ibragimov
Thus, the preparation of folic acid (folacini) can be recommended for wide application in practical public health services in female consultations, maternity hospitals for treatment of anemia’s at pregnant women and women in childbirth in the postnatal period, especially at transferred blood in тhe use and early postnatal the periods or at a Cesarean section. The given preparation is safe; simple in also does not demand additional service (the pregnant woman can easy accept itself).
It is not necessary to stop treatment by preparations of iron after normalization of level of hemoglobin and the maintenance earitrocitis in an organism. Normalization of level of hemoglobin in an organism does not mean restoration of stocks of iron in it. For this purpose experts the CART recommend after 2-3 the monthly treatments and liquidation hematology a picture of an anemia not to stop therapy carrying out, and only to reduce twice a dose of a preparation which was used for treatment against an anemia anemias. Such course of treatment proceeds within 3 months. Even having restored completely iron stocks in an organism expediently during half a year to accept small doses of ferriferous preparations.
Development of an anemia during pregnancy negatively influences a current development process and is the serious factor of braking after a birth adaptations.
Timely and adequate treatment, preventive application shortage of iron in an organism
Preparations from early terms hestacy – pledge of safe end of pregnancy both for mother, and for the newborn.
Earnoseconjunctival syndrome, reality and means under fungal sinusitis and otomycosis
Bustonov M.O., Azizov K.N., Весоv А.А., Dusanova S.B., Kasirova M.Т.
100 patients with chronic sinusitis in combination with chronic otitis media of fungal-bacterial etiology were examined. The control group was formed by 50 chronic otitis media patients.
Clinically, under otomycosis, structural changes appear in three forms: hypertrophic (44%), hydropic (32%) and combined (24%).
ULTRASOUND DIAGNOSTICS THYROID PATHOLOGY IN CHILDREN AND ADOLESCENTS
KASYMOVA S.D., AYUBOVA G.SH., RAHMONOV V.D., BOYMATOVA M.B.
THE COURSE OF ENDOCRINOLOGY AT DEPARTMENT OF THERAPY TIPGPMP REPUBLICAN CLINICAL CENTRE OF ENDOCRINOLOGY
In connection with the exceptional importance of the thyroid gland problem of pathology of the organ of children is the focus of endocrinologists. Pathology of the thyroid gland in the regions of iodine deficiency, which includes the Republic of Tajikistan, occupies the leading position in the endocrine pathology in children and adolescents. Diagnostics of thyroid pathology in this category includes a phased investigation with the decision of the question concerning the goitrous increase the authority and assessment of the functional state of the thyroid gland. Many tasks successfully done with the use of ultrasonic technologies. The article suggests the use of ultrasound diagnostics for estimation of structural and functional changes of the thyroid gland, 93 children and adolescents with a duration of pathology from 6 months to 2 years. Depending on the functional state of the examined organ children and adolescents were divided into the following groups: I group amount¬ed to 61,3% of patients with diffuse nontoxic goiter, II – 20,4% of individuals autoimmune, with tireoidita III group – 18,2% of surveyed with hypopituitarism thyroid gland. Results of ultrasonic research show the greatest increase in volume of the thyroid gland in the group 2 patients with au¬toimmune thyroiditis. Analysis of results of ultrasonic research showed that in the 1 group of the examined enlargement of the thyroid gland was moderately expressed. The largest increase of the volume of the thyroid was noted in group 2 patients with autoimmune thyroiditis. Of the 17 patients with subclinical hypothyroidism last group in 58% of cases of thyroid volume slightly increased in 42% of cases, the value remains in the normal range. The results obtained allow to note that for the estimation of structural and functional changes of the thyroid gland are essential ultrasound diagnostics.
THE CLINICAL ASSESSMENT OF THE APPLICATION OF PERCUTANEOUS NEPHROSTOMY IN PATIENTS WITH VIOLATION OF THE URODYNAMICS UPPER URINARY TRACT
SAIDULLAEV L., NOSIROV D.B.
In the work we have studied the results of percutaneous nephrostomy in 35 patients with violation of the urodynamics upper urinary tract different etiology. Getting the results suggest that percutaneous drainage of the upper urinary tract is малотравматичным, economical and brief intervention, which is very important in relation to almost incurable patients
OPTIMIZATION OF A TACTICAL APPROACH WHEN COMBINED FRACTURES OF LONG BONES
KARIMOV K.K, ASHUROV B.O.,BAROTOV H.N., SHARIPOV U.L.
In the work of the studied result of the treatment of 73 patients with impairment of long tubular bones of the lower extremities, received at the clinic for emergency and planned manner. All patients were complex clinico-diagnostic approach and appropriate treatment.
The result of the study States that early stable-functional osteosynthesis of a grant minimize disability, early activation of the patients, and also the restoration of the static-dynamic functions and kinematic balance of the musculoskeletal system.
The estimation of modern methods of laboratory researches of toxic components of blood in diagnostics of degree of the intoxication of endotoxicose patients
Modern methods of laboratory researches of toxic components of blood of endotoxicose patients are analyzed, and are revealed that as one of markers adequately reflecting intoxication degree at an early stage of development of pathology levels of molecules of the average weights which research is obviously important also perspective with the use of gel-chromatographic and Infrared- spectrometer methods can serve.
REGIONAL PARTICULARITIES OF TRAUMATISM ТРАВМА¬ТИЗМА IN THE REPUBLIC OF TAJIKISTAN
SIRODZHOV K.H., TOLIBOV SH.M., ESHONOV I.E.
Analyzing results of the diagnostics and treatments 300 patients with polytrauma, is revealed specific particularities traumatism in Republics Tajikistan. Prevalence the low high¬speed highways and low floor at home lead less the heavy to damages of a skeleton and low relative density of lethal outcomes to the sharp period of a polytrauma, absence of the doctrine of rendering of primary medical aid at a pre-hospital stage, continuity with presence traumas of the centers 1st and 2nd level in most cases is the reason of high relative density of a traumatic shock, volume blood losses and others the vital infringements.
EVALUATION OF DENTAL CARE IN PATIENTS DEPENDING ON THE INDIVIDUALLY-TYPOLOGICAL STATUS
GUREZOV M.R., MAKHMUDOV D.T.
When using clinical dental scales identified the main types of emotional reactions among dental patients, determining the present status of the examined persons. The use of this scale has enabled us demonstrate rapid diagnostics of the emotional status of patients and at the same time to get positive results of dental treatment on an outpatient reception.