*Qosimov O.I., **Rajabov F.F., ***Shahmatov A.N., ****Bobiev G.M.

*Department of Dermatology and Venereology of Tajik Institute of Post-Graduate Education of Medical Staff

**Laboratory case course of Tajik Institute of Post-Graduate Education of Medical Staff

***JSC "Zand"

****The Chair of Organic and Biological Chemistry, Tajik State Pedagogical University by name S.Ayni

Aim. The study of the effectiveness of application of thymozin in treatment of patients with psoriasis.

Materials and methods. The study involved 60 patients with psoriasis aged 16 to 60 years. Duration of the disease ranged from 1 to several decades. Up to 5 years of life suffer from psoriasis 8, 6-10 years — 18, 10-20 years — 15, years more than 20 — 19 peoples.

In all of them there was a common form of psoriasis. Psoriasis became aggravated in 19 patients mainly after neuropsychiatric stress, and 21 — often because of relapse and concomitant allergic colds, the rest — unjustly.

All patients before and after treatment in addition to general clinical blood tests, including RVs, urine, feces on the I / worm , immunological tests were performed on the absolute and relative content of T- and B- lymphocytes in the peripheral blood, T-lymphocyte subpopulations, serum immunoglobulins CIC, phagocytic number and phagocytic activity of neutrophils.

Results. The vast majority of patients in both treatment groups suffered no side effects and complications. Clinical cure (complete resorption of psoriatic lesions) by the end of the combined treatment was observed in 53,3 % of cases in the study group, a significant improvement (75% complete regression of lesions and more) — 23,4 % improvement (50-75 % regression of lesions) — in 13,3 % of cases.

Summary. The complex treatment of patients with psoriasis with application of thymozin was much more effective than the traditional one. Influenced complex treatment timotsinwas normalized 8 of 9 modified to treat immunological parameters, the traditional — only. Absence of clinical effect of severe hereditary reason explained by hereditary reason.


1. Bobiev G. M. Sposob polucheniya immunostimuliruyushchego preparata timotsin [Method of producing an immunostimulatory preparation timotsin]. Patent RT, no. 282, 1998.

2. Bobiev G. M., Zoipov P. T., Huseynov A. A. Application of the new immunomodulator drug timogar in the treatment of psoriasis and neurodermatitis.

Immunology, 1999, no. 2, рр. 46-49.

3. Bykova V. P., Satdykova G. P. Morphofunctional organization of lymphoepithelial organs of humans pharynx.

Bulletin of the Russian Academy of Sciences. Biology Series, 2002, no. 4, рр. 28-33.

4. Vasilev S. A. Adgezivnye glikoproteiny v patogeneze i lechenii immunokompleksnoy patologii. avtoref. Diss. dok. med. nauk [Adhesive glycoproteins in the pathogenesis and treatment of immunocomplex pathology. Extended abstract of Doctor’s thesis].1996. 46 p.

5. Grinevich Yu. A., Alferova A. I. Determination of immune complexes in the blood of cancer patients.

Laboratory work, 1981, no. 8, pp. 493-495.

6. Dimant L. E. Terapiya bolnykh psoriazom s uchetom immunomorfologicheskikh markerov vospaleniya i proliferativnoy aktivnosti keratinotsitov kozhi. Avtoref. dis. [Therapy of patients with psoriasis based on immunomorphological markers of inflammation and proliferation activity of keratinocyte skin. Extended abstract of candidate’s thesis]. 2001. 16 p.

7. Korotkiy N. G., Urdzhukhu V. Yu. Therapeutic possibilities of thymodepressin in patients with psoriasis and the mechanisms of its therapeutic action.

Bellutin of Dermatology and Venereology, 2002, no. 4, pp. 58-60.

8. Mazina N.M. Genetics of psoriasis: a literature review.

Journal of Dermatology and Venereology, 1993, no. 1, pp.17-19.

9. Mordovtsev V. N. Modern concepts in pathogenesis of psoriasis.

Bellutin of Dermatology and Venereology, 1999, no. 3, pp. 28-33.

10. Petrov R. V., Lopukhin Yu. M., Cheredeev A. N., Otsenka immunnogo statusa cheloveka. Metodicheskie rekomendatsii [Evaluation of humans immune status. Methodical recommendations]. Moscow, 1984. 36 p.

11. Skripkin Yu. K., Mordovtsev V. N.,

Skin and venereal diseases, 1999, vol. 2, pp. 879.

12. Skripkin Yu. K., Samsonov V. A. Modern problems of Dermatology and Venereology.

Bellutin of Dermatology and Venereology, 1997, no. 6, pp. 4-8.

13. Tsvetkova G. M., Mordovtseva V. V., Vavilov A.M. Patomorfologiya bolezney kozhi. Rukovodstvo dlya vrachey [Patomorphology of skin diseases. Manual for Physicians]. Moscow, Meditsina Pub., 2003. 496 p.

14. Yunkerov V. I., Grigorev S. G. Matematiko-statisticheskaya obrabotka dannykh meditsinskikh issledovaniy [Mathematical and statistical data processing of medical research]. St. Peterburg, VMedA Publ., 2002. 266 p.

15. Yarilin A. A. Osnovy immunologii [Fundamentals of Immunology]. Moscow, Meditsina Publ., 1999. 608 p.

16. Baker J. Immunology of psoriasis: the role of immune system. London: Medicine at St. Mauris, 2000.

17. Cooper K. D. Effects of cyclosporine on immunologic mechanisms in psoriasis.

Journal of the American Academy of Dermatology, 1990, Vol. 23, No.6, Pt. 2, pp.1318-26.

18. Guilnou J. J. Immunopathogenesis of psoriasis. New old concept.

Dermatology, 2002, Vol. 197, pp. 310-12.

19. Mancini G., Carbonara A. O., Heremsans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion.

Immunochemistry, 1965, Vol. 2, pp. 235-254.

20. Moretta L, Ferrarini M, Mingari MC., Subpopulations of human T-cells identified by receptors for lg and mitogen responsiveness.

The Journal of Immunology, 1976, Vol. 117, pp. 2171.

21. Sauder D. N., The pluripolent keratinocyte: molecular characterization of epidermal cytokines.

Journal of Investigative Dermatology, 1999, Vol. 90, pp. 605-607.


Back to Top