RELATIONSHIP BETWEEN HYPERURICEMIA AND CARDIOVASCULAR DISEASE
RELATIONSHIP BETWEEN HYPERURICEMIA AND CARDIOVASCULAR DISEASE
Abduloev Kh.Dzh.
Department of therapy with a course of gerontology of State educational establishment «Institute of postgraduate education in health sphere of Republic of Tajikistan»
Aim. Determine the relationship between hyperuricemia with cardiovascular disease
Materials and methods. The study included 56 patients suffering from gout. All patients were identified lipid metabolism. Calculated as atherogenicindex, indirectly determining the aggregate contribution of lipid disorders in atherogen-esis. Lipid profile, total cholesterol was estimated by enzymatic photometric test «Chod-PAP», based on the principle of enzymatic hydrolysis and oxidation. Atherogenic index was calculated by the formula Klimova: (XC — HDL-C) / HDL-C. Index value greater than 4,0 was regarded as an appropriate high risk associated with atherosclerosis development of cardio — vascular diseases. Uric acid in the blood serum was determined using enzymatic photometric test with etiltoluindinom. Diagnosis and assessment of severity of obesity was carried out on the basis of body mass index (BMI) is recommended for use by the WHO. Art. All patients performed ECG in 12 standard leads to cardiograph «Jocare» (Japan). All patients who underwent definition vasoregulating endothelial activity was performed echocardiogram study.
Results.
Among the main FF more frequently observed increase in total cholesterol (89,3%), reduced HDL-C (60,7%) and increased atherogenic index (53,6%) and SBP (57,1%). Most of the patients showed an increase in BMI (85,7%). Visceral type of obesity, which is associated with increased risk of CVD, is set at 90% of gout patients with obesity. Arterial hypertension (AH) occurred in 57,1 % of patients. Among them, 63,6 % of patients were diagnosed with Stage I extent, 18,2% of AH II degree, at 18,2% — Stage III degree. CHD was detected in 32,1 % of patients, of whom 11,1% of patients had a history of myocardial infarction. In 88,9 % of patients were diagnosed with exceptional angina FC I-IV. At 1,8% of patients have a history of cerebrovascular accident. Chronic heart failure, grade I-II was detected in 10,7%, MS was diagnosed in 28,6% of patients studied. Thus, the examined patients we found a high frequency and two more cardiovascular risk factors. According to epidemiological studies, the combination of two or more factors of the patients significantly increases the risk of cardiovascular catastrophes. In 39 (48,7%) patients were various changes in the ECG. Of the other symptoms most commonly detected focal changes infarction (22 patients, accounting for 27,7 %). "Hidden" coronary insufficiency was detected in 7 of 10 patients who underwent bicycle ergometry. Echocardiography (echocardiography) examined 29 patients with gout. Draws the attention of a high percentage (37,9%) patients with aortic dilatation in the area of the aortic valve.
Conclusion.
Thus, MK is able to induce the mechanisms contributing to the occurrence and progression of CVD. The presence of pathology of the cardiovascular system in the examined groups, allows us to consider them not as a co-morbidity, and the circle of symptoms developing on the background of impaired lipid metabolism and purine gout .
REFERENCES
1. Kononenko I. V., Surkova E. V., Antsiferov M. B. Problemy endokrinologii — Problems of Endocrinology, 2009, no. 2, pp. 36-41.
2. Mazurov V. I., Petrova M. S., Belyaeva I. B. Podagra [Gout]. St. Peterburg, 2009. 127 p.
3. Tsoliev T. S. [Features of course of gout, complicated high blood pressure]. Sbornik nauchnikh trudov «Aktualnye voprosy kardiologii» [Collection of scientific works «Pressing questions of cardiology»]. Tashkent, 1991, pp. 61-63. (In Russ.)
4. Tkach S. M. Sovremennye podkhody k lecheniyu gastroezofagealnoy reflyuksnoy bolezni u bolnykh s ozhireniem [Modern approaches to the treatment of gastroesophageal reflux disease in patients with obesity].
Suchasna gastroenterologiya — Modern gastroenterology, 2009, no. 1 (45), pp. 46-50.
5. Uilyams P. T. Effekt diety, fizicheskoj aktivnosti, massy tela na vozniknovenie podagry [The effect of diet, physical activity, body weight on the occurrence gout]. American Journal of Clinical Nutrition, 2008, vol. 87, pp. 7.
6. Khabizhanov V. B. Metabolicheskie narusheniya u bolnykh podagroy [Metabolic infringements in patients with gout]. Konsilium — Consilium, 2008, no. 1-2, pp. 44-45.
7. Chubrieva S. Yu., Glukhov N. V., Zaychik A. M. Zhirovaya tkan kak endokrinnyy regulyator [Adipose tissue as an endocrine regulator]. Vestnik Sankt-Peterburgskogo universiteta. Seriya 11 — Bulletin of St. Petersburg University. Episode 11, 2008.
8. Bergar L., Yu T. Renal function in gout. American Journal of Medicine, 1975, vol. 59, pp. 605-608.
9. Berkowitz D. Gout, hyperlipidemia and diabetes interrelationships. Journal of the American Medical Association, 1966, vol. 197, pp. 77-80.
10. Camerou J., Simmonds H. Uric acid, gout and the kidney. Journal of Clinical Pathology, 1981, no. 34, pp. 1245-1254.
11. Collantes K., Hahones F., Cisnal A. et al. Variability of lipid phenotype in hiperuricemic-hiperlipidemic patients: clinheum. Belgiya, 1994, vol. 13, pp. 1-16.
12. Grundy S. M. Hypertriglyceridemia, insulin resistance and the metabolic syndrome. American Journal of Cardiology, 1999, vol. 83, pp. 25-29.
13. Lawrence R. C., Helmick C. G., Arnett F. C. et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis and Rheumatology, 1998, vol. 41, pp. 778- 99.
14. Leyva F., Anker S., Swan S. W. et al. Serum uricacid as an index of impaired oxidative metabolism in chronic heart failure. European Heart Journal, 2007, vol. 8, pp.858- 865.
15. Mazzali M., Hughes S., Kim Y. G. et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension, 2003, vol. 38, no.5, pp. 1101-1106.
Комментарии