Abdurakhmanova R.F., Izzatov H.N., Hadibaeva G.R., Sharipova B.A.

Department of Neurology and Medical Genetics of State Educational Establishment «Institute of Postgraduate Education in Health Sphere of Republic of Tajikistan»

Cerebrovascular disease is one of the most important medical and social problems. One of the serious consequences of cerebrovascular disease, is a disorder of cognitive functions. Cognitive disorders (CD), along with other neuro­logical disorders are important manifestations of organic brain pathology. Vascular CD in its development through several stages, and the most severe form of cognitive disorders, vascular dementia is (VD). At the CD is dominated neuropsychological symptoms of frontal dysfunction than memory impairment, as well as the presence of neurological symptoms in the early stages of the disease. The main factors of the development of the CD are: arterial hypertension, atherosclerosis, heart disease, diabetes, etc. These factors contribute to the development of lacunar infarcts and leukoaraiosis that precede as moderate CD, well as dementia.

In patients with diabetes are found in 87% of cases of depressive disorders. Joining depression to vascular lesions of the brain, leading to a deepening of the CD. The link between depression and vascular disease is determined by hemo­ dynamic factors, which manifests itself in an increase in blood pressure and a decrease in cardiac output in response to the different emotions of the subjects. Also in depressive disorders marked hypercoagulable syndrome. Neuroimaging techniques reveal functional changes in the brain, depression as a reduction in blood flow and glucose metabolism, mainly in the areas responsible for cognitive functions.


1. Bogolepova A. N. Kognitivnye narusheniya u bolnykh s tserebrovaskulyarnoy patologiey [Cognitive impairment in patients with cerebrovascular disease]. Lechenie nervnykh bolezney — Treatment of nervous diseases, 2011, no. 3 (8), pp. 16-21.

2. Bogolepova A. N., Gusev E. I. Rol protsessov neyro-plastichnosti v razvitii depressivnykh rasstroystv [The role of neuroplasticity processes in the development of depressive disorders]. Trudnyy patsient — The difficult patient, 2010, no. 10, pp. 11-16.

3. Varlou Ch. P., Denis M. S., Prakticheskoe rukovodstvo dlya vedeniya bolnykh [A practical manual for conducting patients]. St. Petersburg, Politekhnika Publ., 1998. 629 p.

4. Geraskina L. A., Suslina Z. A., Tserebralnaya per-fuziya u bolnykh arterialnoy gipertoniey i khronicheskimi formami sosudistoy patologiey golovnogo mozga [Cerebral perfusion in patients with arterial hypertension and chronic forms of vascular disease of the brain]. Terapevticheskiy arkhiv — Therapeutic archives, 2003, no.12, pp. 32-36.

5. Gusev E. I., Konovalov A. N., Klinicheskie re-komendatsii. Nevrologiya i neyrokhirurgiya [Clinical rec­ommendations. Neurology and Neurosurgery]. Moscow, GE'OTAR-Media Publ., 2008. 97-104 p.

6. Gusev E. I., Bogolepova A. N. Kognitivnye narush-eniya pri tserebrovaskulyarnykh zabolevaniyakh [Cognitive impairment in cerebrovascular diseases]. Moscow, MED-press-inform Publ., 2013. 160 p.

7. Zakharov V. V. Kognitivnye narusheniya v nevro-logicheskoy praktike [Cognitive impairment in neurological practice]. Trudnyy patsient — The difficult patient, 2005, no. 5, pp. 1-4.

8. Iznak A. F. Neyronalnaya plastichnost i terapiya affektivnykh rasstroystv [Neuronal plasticity and therapy affective disorders]. Psikhiatriya i psikhofarmakoterapiya -Psychiatry and psychopharmacotherapy, 2004, no. 2, pp. 3.

9. Kadykov A. S. Sostoyanie kognitivnykh funktsiy u bolnykh s nachalnymi proyavleniyami tserebrovaskulyarnoy patologii pri arterialnoy gipertonii I-II stadiy. Avtoref. diss. kand. med. nauk [State of cognitive functions in patients with early manifestations of cerebrovascular disease in patients with arterial hypertension stage I-II. Extended abstract of candidate’s thesis]. Moscow, 2012. 23 p.

10. Kadykov A. S., Khronicheskie sosudistye zabolevaniya golovnogo mozga: netsirkulyatornaya entsefalopatiya [Chronic vascular diseases of the brain: non circulatory encephalopa­thy]. Moscow, GEOTAR-Media Publ., 2013. 232 p.

11. Kadykov A. S., Manvelov A. S., Prakticheskaya nevrologiya [Practical neurology]. Moscow, GEOTAR-Media Publ., 2011. 218-230 p.

12. Kalashnikova L. A. Kognitivnye narusheniya i dementsiya pri tserebrovaskulyarnykh zabolevaniyakh [Cog­nitive impairment and dementia in cerebrovascular diseases]. Atmosfera. Nervnye bolezni — Atmosphere. Nervous Diseases, 2005, no. 2, pp. 36-40.

13. Levin O. S., Golubeva L. V. Kognitivnye rasstroystva [Cognitive disorders]. Meditsinskiy konsilium — Connisilium medicum, 2006, no. 12, pp. 106-110.

14. Odinak M. M., Sosudistye zabolevaniya golovnogo mozga [Vascular diseases of the brain]. St. Petersburg, Gip-pokrat Publ., 2003. 160 p.

15. Olbinskaya L. I., Sizova Zh. M. Khronicheskaya ser-dechnaya nedostatochnost [Chronic heart failure]. Moscow, Reafarm Publ., 2001. 344 p.

16. Parfenov V. A., Starchina Yu. A. Kognitivnye rasstroystva i ikh lechenie u bolnykh arterialnoy gipertenziey [Cognitive disorders and their treatment in patients with ar­terial hypertension]. Russkiy meditsinskiy zhurnal — Russian medical journal, 2007, vol. 15, no. 2, pp. 117-122.

17. Parfenov V. A., Khasanova D. R. Ishemicheskiy insult [An ischemic stroke]. Moscow, MIA Publ., 2012. 228 p.

18. Prenebrazhenskaya I. S., Yakhno N. N. Sosudistye kognitivnye rasstroystva — klinicheskie proyavleniya, di-agnostika, lechenie [Vascular cognitive disorders — clinical manifestations, diagnosis, treatment]. Nevrologicheskiy zhurnal — Journal of neurology, 2001, no. 5, pp. 45-15.

19. Starchina Yu. A., Parfenov V. A. Kognitivnye rasstroystva pri tserebrovaskulyarnykh zabolevaniyakh: diagnoz i lechenie [Cognitive disorders in cerebrovascular diseases: diagnosis and treatment]. Russkiy meditsinskiy zhurnal. Nevrologia — Russian medical journal. Neurology, 2008, vol. 16, no. 12, pp. 1-3.

20. Suslina Z. A. Varakin Yu. Ya. Vereshchagin N. V. Sosudistye zabolevaniya golovnogo mozga [Vascular diseases of the brain]. Moscow, MEDpress-inform Publ., 2009. 352 p.

21. Suslina Z. A., Piradov M. A. Insult: diagnostika, lech-enie, profilaktika [Stroke: diagnosis, treatment, prevention]. Moscow, MEDpress-inform Publ., 2008. 288 p.

22. Tul Dzh. F. Sosudistye zabolevaniya golovnogo mozga: Rukovodstvo dlya vrachey [Vascular diseases of the brain: A manual for physicians]. Moscow, GEOTAR-Media Publ., 2007. 590 p.

23. Fonyakin A. V. Ishemicheskiy insult: kardinalnaya patologiya v patogeneze, techenii i prognoze. Avtoref. diss. dokt. med. nauk [An ischemic stroke: a cardinal pathology in the pathogenesis, clinical course and prognosis. Extended abstract of Doctor’s thesis]. Moscow, 2000. 40 p.

24. Shtulman D. R., Levin O. S. Nevrologiya: spravoch-nik prakticheskogo vracha [Neurology: handbook for the practicing physician]. Moscow, MEDpress-inform Publ., 2004. 864 p.

25. Yakhno N. N., Zakharov V. V., Lokshina A. B., De-mentsii: Rukovodstvo dlya vrachey [Dementia: A manual for physicians]. Moscow, MEDpress-inform Publ., 2010. 272 p.

26. Barnes D. E., Depressive symptoms, vascular disease, and mild cognitive impairment. Findings from the cardio­vascular health study. Archives of General Psychiatry, 2006, vol. 63, pp. 273-280.

27. Enzinger Ch., Smith S., Lesion probability maps of white matter hyperintensities in elderly individuals results of the Austrian stroke prevention study. Journal of Neurology, 2006, vol. 253, pp.1064-1070.

28. Ferri C. P., Prince M. Global prevalence of demen­tia: a Delphi consensus study. Lancet, 2005, vol. 366, pp. 2112-2117.

29. Gauthier S., Toucchon J. Sub classification of mild cognitive impairment in research and clinical practice. Alzheimer's Diseases and Related Disorders Annual, 2004, pp. 61-70.

30. Jajodia A., Borders A. Memory predicts changes in depressive symptoms in older adults: a bidirectional longi­tudinal analysis. Journal of Gerontology, 2011, vol. 66, no. 5, pp. 571-581.

31. Modgero P. L., Ferrandez J. Depression in patients with mild cognitive impairment increases the risk of devel­oping dementia of Alzheimer type. A prospective cohort study. Archives of Neurology, 2004, vol. 61, pp. 1290-1293.

32. Musselman D. L., Marzec U. M., Manatunga A.. Platelet reactivity in depressed patients treated with parox­etine: preliminary findings. Archives of General Psychiatry, 2000, vol. 57, pp. 875-882.

33. Roman G. C., Erkinjuntii T., Wallian A. et al. Sub­cortical ischemic vascular dementia. Lancet of Neurology, 2002, vol. 1,pp. 426-436.

34. Steffens D. C., Bosworth H. B., Subcortical white matter lesions and functional impairment in geriatric depres­sion. Depress Anxiety, 2002, vol. 15, pp. 23-28.

35. Taylor W.D., MacFalll J.R., Greater MRI lesion volumes in elderly depressed subjects then in control subjects. Psychiatry resources, 2005, vol. 139, pp. 1-7.

36. Thomas A.L. et al. Depression and vascular disease: what is the relationship. Journal of Affective Disorders, 2004, vol. 79, no. 1-3, pp. 81-95.

37. Trojano C., Anderson C., Chapman N. et al. Cognitive Impairment: a key feature of congestive heart failure in the elderly. Journal of Neurology, 2003, vol. 250, pp.1456-1463.

38. Vogels R. L., Oosterman J. M., Harten van B.,Neuro-imaging and correlates of cognitive function among patients with heart failure. Dementia Geriatric Cognitive Disorders, 2007, vol. 24. no. 6, pp. 418-428.

39. Waldemar G., Dubois B., Emre M., Recommenda­tion for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guide­line. European Journal of Neurology, 2007, vol. 14, pp. 1-26.

40. Winter Y. Y., Korchounov A., Zhukova T. V., Bertschi N. E. Depression in elderly patients with Alzhei­mer dementia and its influence on quality of life. Journal of Neuroscience in Rural Practice, 2011, vol. 2, no. 1, pp. 27-32.


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