Narzullaeva A.R., Shohzodaeva Z.O., Sharipova F.
REIEW OF BISOPROLOL EFFICIENCY IN CARDIOVASCULAR DISEASES THERAPY
Department of Cardiology with the course of clinical pharmacology of the State Education Establishment “Institute of Postgraduate Education in Health Sphere of Republic of Tajikistan”
Considering the pathophysiological and etiopathogenetic preconditions purpose of beta-blockers in cardiovascular diseases, as well as their ability to improve health and life prognosis of patients with very high cardiovascular risk, the review covered issues of bisoprolol application in the treatment of cardiovascular diseases. After analyzing of its clinical pharmacology have been provided evidence from randomized controlled studies that show its high efficiency and safety in the pharmacotherapy of diseases such as hypertension, coronary heart disease, chronic heart failure. Bisoprolol has a strong cardioprotective effect. Different by minimal side effects, metabolic neutrality, and positive influence on prognosis of cardiovascular diseases. High-P1-selectivity of bisoprolol make safe its application in patients with chronic obstructive pulmonary disease and metabolic disorders as well as opens up the possibility of its use in patients with underlying liver and kidney function without correction dose of drug. Debated question of the application of this drug for the treatment of cardiovascular disease in pregnant women and nursing. In addition, pharmacokinetic characteristics contribute to high adherence and does not degrade the quality of life of patients with various diseases of the cardiovascular system. Regular and long-term treatment of hypertension, angina, chronic heart failure with bisoprolol leads not only to reduce blood pressure to target levels, organoprotective effect, reduce the frequency of angina attacks and symptoms of heart failure, but also a substantial reduction of serious complications, thereby improving the health and life prognosis of patients, increasing their life span.