DYNAMICS IMMUNOLOGICAL INDICES IN PATIENTS OF CHRONIC GENERALIZED PERIODONTITIS DURING THERAPY WITH MELLINOL
Akhrorova Z.K., Komilov F.M., Nosirov A.F., Fayzov K.S.
The department of orthopedic stomatology TIPGPMP
With the purpose of correction of immunological changes in dental patients has been studied the influence of the drug mellinol in the treatment of generalized periodontitis in 32 patients with chronic viral hepatitis b and C. The results obtained show that in the group of patients with chronic viral hepatitis b and C using the drug significantly increased rates of T-lymphocyte subpopulations of T-helpers, a marked increase the number of B-lymphocytes and natural killer cells, and increased the number of cells expressing a chain of the IL-2 receptor and receptor to transferrin that shows a marked improvement periodontal status among the surveyed population. Initially reduced rates of T-lymphocytes and T-helpers, expression markers of activation, as a manifestation of immune dysfunction in patients with chronic viral hepatitis b and C, during the therapy with mellinol significantly increased. When using the drug in the least degree of expression is subjected to a subpopulation of cytotoxic T-lymphocytes, which are responsible for the clearance of the virus and the production of cytokines, controlling viral replication. It is revealed that the immunotropic effects of the drug mellinol of periodontal patients with chronic viral hepatitis b and C is manifested positively, regardless of the type of virus that caused the disease, and correlates with the notable restoration of fabrics of parodont.
1. Kukushkina E. A. Vliyanie immunomoduliruyushhey terapii na pokazateli immuniteta i nespetsificheskoy rezistentnosti bol'nykh paro-dontitom. Diss. kand. med. nauk [Impact of immunomodulatory therapy on immunological parameters and nonspecific resistance of periodontitis patients. Cn. med. sci. diss]. 2004.
2. Mansurov X.X., Mansurova F.D., Akhmedova M.D. Gepatoprotektor Mellinol® v terapii zabolevaniy pecheni: Metodicheskie rekomen-dacii dlya vrachey [Hepatoprotector Mellinol ® in the treatment of liver disease: Methodical recommendations for physicians].
3. Saldusova I.V. Rol' immunodefetsitnogo sostoyaniya polosti rta v razvitii parodontita i obosnovanie metodov korrektsii. Avtoreferat diss. kand. med. nauk [The role of immunodeficiency of the oral cavity in development periodontitis and justification of methods for correction. Cn. med. sci. abstract diss.] Moscow, 1997. 24 p.
Information about the authors:
Ahrorova Zulfiya Komiljonovna — the assistance of department of orthopedic stomatology TIPGP-MP, cn. med. sci.; Tel: (992) 919164286; e-mail: firstname.lastname@example.org