Аннотация

Цель
Тo evaluate the prognostic significance of immunological markers (CD4+, CD8+, NK cells, IL-6, TNF-α, IL-10) for identifying the risk of recurrent infections in kidney transplant recipients, as well as to determine the association of these markers with graft function and clinical outcomes.
Материал и методы
Тhis retrospective study included 125 patients, who were divided into two clinical groups: a group without diabetes mellitus (n = 60) and a group with type 2 diabetes mellitus (n = 65). Demographic characteristics, infection history, renal function parameters (eGFR and serum creatinine), and immunological markers (CD4+, CD8+, NK cells, IL-6, TNF-α, and IL-10) were analyzed.
Результаты
Тhe incidence of recurrent infections was significantly higher in patients with diabetes mellitus compared to those without diabetes (43% vs. 23%, p = 0.02). Diabetic recipients demonstrated reduced graft function (eGFR 56 ± 9 mL/min/1.73 m² vs. 61 ± 8 mL/min/1.73 m²; serum creatinine 130 ± 18 µmol/L vs. 118 ± 14 µmol/L; p < 0.05). The immunological profile in diabetic patients was characterized by decreased CD4+ and CD8+ levels and increased IL-6 and TNF-α concentrations, indicating an imbalance of the immune response.
Заключение
Diabetes mellitus increases the risk of recurrent infections, impairs graft function, and disrupts immune status in kidney transplant recipients. Identification of key immunological markers enables prediction of infectious risk and supports the development of personalized strategies for monitoring and therapeutic management.

Ключевые слова

kidney transplantation diabetes mellitus recurrent infections immune status CD4+ IL-6 TNF-α

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Список литературы

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