Tag Archives: diagnostics

DETERMINATION OF TOTAL IMMUNOGLOBULIN CLASSES M AND G – INFORMATIVE METHOD OF DIAGNOSIS OF GIARDIASIS, ASCARIASIS

Aim. Conducting a study on the presence of total immunoglobulin classes M and G to antigens of ascarids, giardia in human blood by immunoenzyme analysis.
Materials and methods. The study involved 35 family members living in the city of Dushanbe GTSZ N»1 without complaints. There were 19 (54%) men and 16 (46.0%) – women.
Results. During the study of blood for presence of total immunoglobulin classes M and G to antigens of Ascaris, by ELISA positive results were found in 14 (31,4%) members of the family: 8 women (57,1%), 6 males (42,8%); 8 (57,1%) had organized (working) population, 6 (42,8%) of unorganized (non-working). In our study, the titer of antibody was determined to determine the duration of the disease. By titration of AT 1:100 – 5 (35,7%), AT-1: 200 – 9 (64,9%). In the study of antibodies to roundworm found that the infestation is more common among females, have organized a contingent of the population. Of those studied, 64.9% of family members infected with ascariasis.
Blood test for the presence of total immunoglobulin classes M and G lamblia antigens by ELISA revealed positive responses in 10 persons (28,5%) among the surveyed family members, of whom – 4 women (40,0 %), 6 men (60%). Of the total number of persons with a positive result to the antigens of Giardia organized (working) – 8 (80%), fugitive (non-working) – 2 people (20%). According to the definition of titer: AT-1:200 – 8 people (80%), AT-1:800 – 2 person (20%). Of the total study 20% of family members infected with Giardia, the prevalence of greater among organized among males.
Conclusion. Concurrent use of koprological and serological methods of diagnosis allows more reliably and efficiently identify ascariasis, giardiasis.

EFFECTIVENESS OF DIAGNOSTICS AND TREATMENT OF MULTIDRUG RESISTANT FORM OF TUBERCULOSIS

Aim. Examine the effectiveness of diagnostic and effectiveness of treatment of multidrug-resistant tuberculosis in Re¬public of Tajikistan.
Materials and methods. Performed analysis of an officially published statistics on drug-resistant tuberculosis from 2008 to 2012, of the National Center for Tuberculosis Control in the framework of the “Program to protect the population from tuber¬culosis in Republic of Tajikistan for 2010-2015”.
Results. Drug resistance to antituberculosis drugs (anti-TB drugs) started to define with the support of WHO. In 2008 in Dushanbe and Rudaki district (population 324 thousand. man – 13,9% of the countrys population). Cultures studied in supranational laboratory in Gauting (Germany). The first study on drug resistance was conducted in 2008-2009 to the main anti-TB drugs. Multidrug resistance was 16.8% among newly diagnosed patients, including previously treated – 61%. The second study – a test to determine drug susceptibility (DST) – carried out in 2010-2011: cases of MDR-TB were 13% and 53,6%, respectively (a decrease among new cases 3.8% among the patients treated early – on 7,4%).
Conclusion. Obtained results indicate a qualitative improvement of indicators of effectiveness of treatment of patients with MDR-TB in the republic – from 53% to 58,4%, mortality rate decreased from 14,2% to 11,3%.
Key words: efficiency, diagnostics, treatment of drug-resistant forms of tuberculosis

The estimation of modern methods of laboratory researches of toxic components of blood in diagnostics of degree of the intoxication of endotoxicose patients

Tuychiboeva M.N.

Modern methods of laboratory researches of toxic components of blood of endotoxicose patients are analyzed, and are revealed that as one of markers adequately reflecting intoxication degree at an early stage of development of pathology levels of molecules of the average weights which research is obviously important also perspective with the use of gel-chromatographic and Infrared- spectrometer methods can serve.

The results of analysis of blood characteristics of the patients with sepsis and estimation of markers of its toxic components

Tuychiboeva M.N., Ahmedova A.A., Mu- hammadnazirzoda N., Muradov A.M.
Results of analysis of blood characteristics of the patients with sepsis and estimation of its toxic components markers are presented, and revealed that as one of markers adequately reflecting intoxication degree at an early stage of development of pathology levels of molecules of the average weights which research is obviously important and also perspective with the use of gel-chromatographic and Infrared- spectrometer methods can serve.