COMPARATIVE EVALUATION OF EFFICIENCY APPLICATION OF MODERN METHODS OF DIAGNOSTICS TOXIC BLOOD COMPONENTS DURING ENDOTOXEMIA
TUYCHIBOEVA M.N., MURADOV A.M. SHUKUROV T., SHUMILINA O.V.
COURSE “LABORATORY WORK” TIPGPMP
One of the most urgent problems in the structure of modern somatic pathology remains endo¬toxicosis, which is a basic component of the formation of the severity of the General condition. The article presents the results of analysis of toxic blood components 206 patients endotoxemia developed in the result of acute renal failure, peritonitis and septicemia in comparison with the figures of 20 healthy donors. Material for the study served as the blood of patients aged from 17 to 62 years, of which men made up 59,3% of women – 40,3%. The study used biochemical, gel-chromatography and infrared spectroscopic methods of diagnostics indicators token to reflect the level of intoxication. Found that the toxicity index in patients endotoxemia increases by more than 700%, compared with the control. On the basis of carried out research we can conclude that the patients endotoxemia occur intensification of lipid peroxidation, depression of immunity, reduction in antioxidant protection and detoxification abilities of organism. The comparison of the curves fractionation of blood plasma during endotoxemia and in healthy people showed that the patients of the main group there was a significant increase in fractions of A and D, to a lesser extent faction Century There was a tendency to a decrease in blood levels of medium-weight molecules due to their concentration redistribution that may be characteristic only for endotoxicosis